HLA-DR2 and Narcolepsy
نویسندگان
چکیده
منابع مشابه
HLA-DR2 negative narcolepsy.
Letters Cigarette smoking, Parkinson's disease and ulcerative colitis Sir: Individuals who develop Parkinson's disease are about twice as likely to have been habitual non-smokers when compared with a control population.`1 Smoking also seems to exert considerable protective effects against ulcerative colitis.46 It has been suggested that both these illnesses may be associated with inflexible, mo...
متن کاملDR2-positive monozygotic twins discordant for narcolepsy.
Narcolepsy runs in families, and recent research has revealed the human leukocyte antigen (HLA) DR2 to be a genetic marker closely associated with the disease. But, as indicated by family studies, other factors contribute to the pathogenesis of narcolepsy. The investigation of monozygotic twins is the most specific research tool for distinguishing between a multigenetic and a multifactorial pat...
متن کاملNarcolepsy associated with primary temporal lobe B-cells lymphoma in a HLA DR2 negative subject.
Narcolepsy and cataplexy began one year before treatment of a left mid-temporal primary B-cells lymphoma in a HLA DR2 negative man. Treatment with radio therapy and immunosuppression induced regression of the lymphoma and disappearance of narcolepsy and cataplexy.
متن کاملSchizophrenia, narcolepsy, and HLA-DR15, DQ6.
A strong association between HLA-DR2, DQ1 and narcolepsy-cataplexy has been known since 1986. In 1990 a subdivision (HLA-DR15, DQ6) was shown to be equally associated. Narcolepsy symptoms include rapid eye movement (REM)-sleep intrusion hallucinations during the day. Some narcoleptics may be so hallucinated that they become delusional and receive a diagnosis of schizophrenia. Fifty-six inpatien...
متن کاملHLA-DR2 in two sibships with insulin-dependent diabetes mellitus.
We report two families selected from 124 genotyped Caucasian insulin-dependent diabetes mellitus (IDDM) families because of unusual features. In both families, all offspring are affected and four out of six bear the allele HLA-DR2 which is an uncommon phenotype among diabetic patients. Onset before the age of 1 year in all the patients of one family, association with optic atrophy in the other,...
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ژورنال
عنوان ژورنال: Sleep
سال: 1986
ISSN: 0161-8105,1550-9109
DOI: 10.1093/sleep/9.1.149